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G., Mariman, E
HA and IR can exacerbate endothelial damage and disrupt endothelium-dependent vasodilation mechanisms, leading to vascular smooth muscle hypertrophy and lipid metabolism disorders (Krentowska and Kowalska, 2022
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Plasma membrane rupture in necrotic cells triggers the extracellular release of substances, including ATP, potassium ions, uric acid, high-mobility group box 1 protein, and S100 calcium-binding proteins
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